SPICE | Version 1.0
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SPICE

Structural Protein Interaction Complex Evaluator

Advanced computational platform for analyzing protein-protein interactions,
structural properties, and generating publication-quality visualizations

Fast Analysis
Secure Processing
Rich Visualization

Choose Your Analysis Mode

Select the appropriate analysis workflow for your research needs

Single Complex Analysis

Comprehensive structural analysis of individual protein complexes with detailed interaction mapping and visualization

  • Upload or fetch PDB structures
  • Contact analysis (H-bonds, salt bridges)
  • Interface residue identification
  • SASA calculations
  • VdW interaction energy analysis
  • Geometric analysis & distance matrices
  • Interactive 3D visualization

Multi-Complex Comparison

Compare multiple structural variants against a wild-type reference with comprehensive statistical analysis

  • Upload multiple PDB structures
  • Designate wild-type reference
  • Define chain groups (antibody/antigen)
  • Side-by-side variant comparison
  • Statistical analysis with p-values
  • Publication-quality plots
  • Export data (CSV/Excel)

Key Features

Comprehensive tools for protein structure analysis

Interactive Visualizations

Explore results dynamically with interactive HTML-based visualizations, allowing real-time data exploration and insight discovery

Modular Analysis

Select only the analyses you need with checkbox-based selection, customizing your workflow for maximum efficiency

Publication Ready

Generate high-quality visualizations and export data in formats ready for scientific publications

3D Visualization

Interactive molecular viewers for intuitive exploration of protein structures

PDB Integration

Direct fetching from RCSB PDB database or upload your own structures for immediate analysis

Secure & Private

Your data is processed securely with session isolation, ensuring privacy and data integrity